The Synthesis of Bis(dichloroacetyl)diamine Derivatives for Cancer Treatment

Posted May 10th, 2010 at 2:47 pm.

Natalee Smith

Mentor: Professor W. Malachowski

Interest in bis(dichloroacetyl)diamines (Figure 1) sparked in the late 1950’s to early 1960’s as this class of compounds was found to have antispermatogenic properties. This interest seemed to have dissipated during the late 20th century; however, a renewed interest has been placed in this class of compounds, which, in addition to having antispermatogenic properties, has been found to have cancer treatment capabilities. The aim of my summer research is to synthesize a series of these compounds, by varying the R groups attached. The resulting compounds will then be tested for their effectiveness as therapeutic treatments.

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Figure 1

Surrey, A. R, and Mayer, R. J., 1961, The preparation and Biological Activity of some N,N’-Bis(haloacyl)-polymethylenediamines, Journal of Medicinal and Pharmaceutical Chemistry, v 3, no 3, p. 419- 425.

Filed under: 2007,Malachowski, Dr. William,Smith, Natalee by Ann Dixon

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