Mentor: Dr. W. Malachowski
Cancer is a disease that affects millions of people worldwide, and is the 2nd leading cause of deaths in the United States. It is thought that indolamine deoxyhydrogenase oxide (IDO) plays a role in immunosuppression, allowing tumors to grow in the body undetected. It has been shown that IDO inhibitors are able to slow the progress the cancer in conjunction with chemotherapy. By using computer modeling, molecules that may be more potent inhibitors than those that currently exist have been proposed. The purpose of thus study is to find synthetic methods to create these molecules in fewer steps and greater yield.