Synthesis of Bis(bpy)-Ru-L-Pteridine

Posted June 22nd, 2010 at 2:46 pm.

Abstract: Alexandra Gaudette
Mentor: Dr. Burgmayer
Ruthenium pteridine complexes have been widely studied for their ability to intercalate between bases of DNA. Intercalation stiffens the DNA molecule, preventing it from replicating. When irradiated in the presence of DNA, some Ruthenium-pteridine complexes have been shown to photocleave. Because of these properties, Ruthenium complexes are being explored as anti-cancer drugs. The Burgmayer group has synthesized and studied many bis(bipyridine)-Ruthenium complexes with substituted pteridine ligands. This summer, I will attempt to create and isolate the unsubstituted pteridine ligand complex and determine its ability to intercalate and photocleave. Preliminary results have shown that the unsubstituted pteridine complex cannot be made cleanly using the same technique used in other ruthenium complex syntheses. Syntheses of this complex monitored by mass spectroscopy suggest the unsubstituted pteridine complex reacts with water, ethylene glycol, air, and even itself during the synthesis reaction. Similar to other Ruthenium complexes, the pteridine ring on the ligand loses a carbon and opens, creating another potential DNA photocleaver. Changing the reaction conditions may afford a cleaner product.

Filed under: 2010,Burgmayer, Dr. Sharon,Gaudette, Alexandra Tags: by Lisa Klinman

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