Examining the Correlation Between Frontal Lobe Functioning with MMN and P300 Outputs

Posted June 24th, 2010 at 1:30 pm.

Abstract:Stephanie Miller and Julia Petre
Mentor: Dr. Thapar
The primary focus of this research study is to establish the value of ERP imaging for studying the effects of aging on cognitive processes. The long term goal is to compare ERP data from younger and older adults to determine specific effects of aging on the underlying neuronal processes. Mismatch negativity (MMN) and P300 are two particular ERP wave form outputs that are produced by involuntary (preattentive) and voluntary shifts in attention, respectively. Changes in amplitude and latency of MMN and P300 may indicate aspects of neuronal activity responsible for cognitive decline in aging. Previous findings suggest that the prefrontal cortex is involved in the generation of MMN and P300, and abnormalities in these outputs may be linked to structural abnormalities in the brain. Cognitive decline due to aging implicates executive functions that are usually generated in the frontal cortex. This study will examine the correlation between frontal lobe functioning with MMN and P300 outputs.

Filed under: 2010,Miller, Stephanie,Petre, Julia,Thapar, Dr. Anjali Tags: by Lisa Klinman

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