An exploration of the reactivity of pteridine based ligands in Ru(II)-bis(bibbyridine)-pteridinyl complexes.

Posted July 25th, 2011 at 6:59 pm.

Abstract: Emily Gaudette

Mentor: Sharon Burgmayer

The Burgmayer group has synthesized a family of bis(bipyridine) Ru(II) complexes with a third pteridine based ligand that can intercalate with DNA.  Some of these complexes have also been shown to cleave DNA when exposed to UV light.  However, the unique chemical behavior some of these complexes has proved equally interesting.  When coordinated to Ru(II) the pteridine ligand is much more reactive.  The unsubstituted form of the pteridiene based ligand has been shown to form adducts with protic solvents and dimerize under certain conditions. When synthesized in methanol, the methanol adds across the carbon-nitrogen double bond on the terminal ring forming the methanol adduct (1). The methanol on this adduct will exchange if dissolved in other alcohols. The terminal ring of this complex also spontaneously cleaves in aqueous solution giving an unsubstituted ring-opened complex (2).  This summer I will further explore this complicated heterocyclic chemistry using 1D and 2D NMR, electrospray ionization mass spectrometry, and cyclic voltametry.  I will also attempt to grow crystals of the complexes for analysis by x-ray crystallography.

Filed under: Uncategorized by Michelle Han

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